AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain–domain interaction prediction
نویسندگان
چکیده
منابع مشابه
AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain-domain interaction prediction
MOTIVATION Most proteins consist of multiple domains, independent structural and evolutionary units that are often reshuffled in genomic rearrangements to form new protein architectures. Template-based modeling methods can often detect homologous templates for individual domains, but templates that could be used to model the entire query protein are often not available. RESULTS We have develo...
متن کاملAIDA: ab initio domain assembly server
AIDA: ab initio domain assembly server, available at http://ffas.burnham.org/AIDA/ is a tool that can identify domains in multi-domain proteins and then predict their 3D structures and relative spatial arrangements. The server is free and open to all users, and there is an option for a user to provide an e-mail to get the link to result page. Domains are evolutionary conserved and often functio...
متن کاملAb Initio Protein Structure Prediction
Predicting protein 3D structures from the amino acid sequence still remains as an unsolved problem after five decades of efforts. If the target protein has a homologue already solved, the task is relatively easy and high-resolution models can be built by copying the framework of the solved structure. However, such a modelling procedure does not help answer the question of how and why a protein ...
متن کاملPrediction Accuracy Evaluation of Domain and Domain Combination Based Prediction Methods for Protein-Protein Interaction
Since the proposal of domain based protein-protein interaction prediction method by [3], there are many attempts to improve domain based protein-protein interaction prediction methods [1]. Among them, domain combination based protein-protein interaction method by [2] is quite appealing in the sense that it achieves very impressive prediction accuracy in some situations. However there is no conc...
متن کاملAb initio protein structure prediction: progress and prospects.
Considerable recent progress has been made in the field of ab initio protein structure prediction, as witnessed by the third Critical Assessment of Structure Prediction (CASP3). In spite of this progress, much work remains, for the field has yet to produce consistently reliable ab initio structure prediction protocols. In this work, we review the features of current ab initio protocols in an at...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2015
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btv092